Transcriptional activation by small RNA duplexes.

نویسنده

  • John J Rossi
چکیده

1. Esengil, H. et al. Nat. Chem. Biol. 3, 154–155 (2007). 2. Jung, D.W. et al. Mol. Biosyst. 1, 85–92 (2005). 3. Khersonsky, S.M. et al. J. Am. Chem. Soc. 125, 11804–11805 (2003). 4. Peterson, R.T. et al. Proc. Natl. Acad. Sci. USA 97, 12965–12969 (2000). 5. Iversen, P.L. & Newbry, S. Curr. Opin. Mol. Ther. 7, 104–108 (2005). 6. Weber, W. & Fussenegger, M. Handb. Exp. Pharmacol. 178, 73–105 (2007). 7. Rubinstein, A.L. Curr. Opin. Drug Discov. Devel. 6, 218–223 (2003). 8. Adam, A., Bartfai, R., Lele, Z., Krone, P.H. & Orban, L. Exp. Cell Res. 256, 282–290 (2000). 9. de Graaf, M., Zivkovic, D. & Joore, J. Dev. Growth Differ. 40, 577–582 (1998).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

افزایش بیان اختصاصی ژن Cdk9 بوسیله microRNA-1 بالغ تک رشته در سلول های فیبروبلاست

Abstract Background: MicroRNAs (miRNAs) are endogenous, non-coding short RNAs (~22 nt) that can downregulate gene expression by translational repression, mRNA degradation, or transcriptional repression. miRNA misregulation has been implicated in pathogenic alterations such as cancer. In order to investigate microRNA functions in gene regulation and/or to modulate their expression in pathogenic...

متن کامل

Transcriptional regulation by promoter targeted RNAs.

Small RNA molecules, including small interfering RNA (siRNA) and micro RNA (miRNA), have rapidly emerged as important regulators of gene expression. Recent articles have demonstrated RNA mediated complex induced transcriptional gene silencing (TGS) occurring in the nucleus. Originally the small RNA mediated TGS pathway has been reported in yeast and plants, currently a number of articles strong...

متن کامل

Using Small RNA-seq Data to Detect siRNA Duplexes Induced by Plant Viruses

Small interfering RNA (siRNA) duplexes are short (usually 21 to 24 bp) double-stranded RNAs (dsRNAs) with several overhanging nucleotides at both 5'- and 3'-ends. It has been found that siRNA duplexes bind the RNA-induced silencing complex (RISC) and cleave the sense strands with endonucleases. In this study, for the first time, we detected siRNA duplexes induced by plant viruses on a large sca...

متن کامل

Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs.

Synthetic small interfering RNA (siRNA) duplexes are widely used to transiently and sequence-specifically disrupt gene expression in mammalian cultured cells. The efficiency and specificity of mRNA cleavage is partly affected by the presence of the nontargeting "passenger" or "sense" siRNA strand, which is required for presentation of the target-complementary or guide siRNA strand to the double...

متن کامل

Npgrj_nbt_1051 222..226

RNA interference (RNAi) is the process of sequence-specific post-transcriptional gene silencing triggered by double-stranded RNAs1–3. In attempts to identify RNAi triggers that effectively function at lower concentrations, we found that synthetic RNA duplexes 25–30 nucleotides in length can be up to 100-fold more potent than corresponding conventional 21-mer small interfering RNAs (siRNAs). Som...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Nature chemical biology

دوره 3 3  شماره 

صفحات  -

تاریخ انتشار 2007